Ansamycin Antibiotics as Free Radical Scavengers Isolated from Streptomyces by Using the Bactericidal Action of the Hydroxyl Radical

Yasujiro MORIMITSU; Akira HIROTA

doi:10.1271/bbb.60.1507

Bioscience, Biotechnology, and Biochemistry

Online ISSN : 1347-6947
Print ISSN : 0916-8451

Ansamycin Antibiotics as Free Radical Scavengers Isolated from Streptomyces by Using the Bactericidal Action of the Hydroxyl Radical

Yasujiro MORIMITSU, Akira HIROTA

Author information

Keywords: radical scavenger, Fenton reaction, bactericidal action, Streptomyces, ansamycin antibiotics

JOURNAL FREE ACCESS

1996 Volume 60 Issue 9 Pages 1507-1509

DOI https://doi.org/10.1271/bbb.60.1507

Details

Abstract

Ansamycin antibiotics (1-4) were isolated from the cultured broth of Streptomyces sp. USF-319 strain as a result of our screening for free radical scavengers. They inhibited the bactericidal effect of the Fenton reagent toward Bacillus subtilis by their radical scavenging activity. Some of them also showed inhibitory activity against lipid peroxidation and lipoxygenases.

Content from these authors

This article cannot obtain the latest cited-by information.

Favorites & Alerts

Corresponding author

Register with J-STAGE for free!