Stimulation of Tumor Necrosis Factor and Interleukin-1 Productivity by the Oral Administration of Cabbage Juice to Rats

Abstract

The effect of orally administering cabbage juice on tumor necrosis factor α (TNF) and interleukin-1 (IL-1) productivity was studied in resident peritoneal macrophages from normal and hepatoma-bearing rats. The productivity of TNF and IL-1 was stimulated by gastric intubation of cabbage juice in the normal state, but not in the hepatoma-bearing state where the production of these cytokines had already been stimulated. From these results, cabbage may contain some effective component(s) that can be absorbed from the gastrointestinal tract to stimulate the production of TNF and IL-1.