Author's Organization：Pharma Research and Development Division, Drug Discovery Research Laboratories, Hoechst Japan Limited:(Present address)Showa College of Pharmaceutical Sciences Pharma Research and Development Division, Drug Discovery Research Laboratories, Hoechst Japan Limited Pharma Research and Development Division, Drug Discovery Research Laboratories, Hoechst Japan Limited Pharma Research and Development Division, Drug Discovery Research Laboratories, Hoechst Japan Limited
We found that daidzein stimulated bone resorption in the pit formation assay at the concentration of 10-8-10<-10&t; M. On the other hand, genistein and ipriflavone at these concentrations did not have any effect on pit formation. We speculated that daidzein had the ability to induce osteoclasts directly or indirectly from their progenitors and might be a tool to study osteoclast differentiation.
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