Effects of Lactobacillus gasseri SBT2055 on Dextran Sulfate Sodium-Induced Ulcerative Colitis Model in Rats

Eiichi IMAI; Kenji FUKUI; Noriyasu OHTA; Toshie TOMITSUKA; Yasuyuki SETO; Shigeru FUJIWARA; Hiroaki MASUNAGA

doi:10.12938/bifidus1996.21.179

Effects of Lactobacillus gasseri SBT2055 on Dextran Sulfate Sodium-Induced Ulcerative Colitis Model in Rats

Eiichi IMAI, Kenji FUKUI, Noriyasu OHTA, Toshie TOMITSUKA, Yasuyuki SETO, Shigeru FUJIWARA, Hiroaki MASUNAGA

著者情報

キーワード: Lactobacillus gasseri, ulcerative colitis, probiotics, dextran sulfate sodium, rat

ジャーナルフリー

2002 年 21 巻 3 号 p. 179-183

DOI https://doi.org/10.12938/bifidus1996.21.179

詳細

抄録

The effects of a Lactobacillus gasseri SBT2055 (LG2055) on ulcerative colitis (UC) were studied in a rat model of UC induced by dextran sulfate sodium (DSS). Daily oral administration of LG2055 improved the characteristics of feces, body weight gain and food consumption. LG2055 treatment was also associated with a change of the spleen weight, and an improvement of the hematological parameters and histological findings of the large intestine. These findings indicate that LG2055 may be useful for the treatment and/or prevention of UC.

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