Biocontrol Science
Online ISSN : 1884-0205
Print ISSN : 1342-4815
ISSN-L : 1342-4815
Formation of a Chlorhexidine Degradation Intermediate through Pyruvate Incorporation by Pseudomonas sp. no.A-3
MASARU UYEDAKEITAROU SUZUKIKAZUMI YOKOMIZOHISASHI KAWATATAEKO SHIOSAKIKEITA WATANABEYUICHIRO MORIYUTAKA KIDO
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1997 年 2 巻 1 号 p. 35-38

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Pseudomonas sp. strain no. A-3 (abbreviated as A-3) was able to degrade chlorhexidine to a chlorhexidine degradation intermediate (abbreviated as CHDI-B). We investigated the formation of CHDI-B, and its antibacterial activities. By the addition of [1-14C] pyruvate, [1-14C] lactate or [1-14C] propionate to the incubation mixture, the incorporation of [1-14C] pyruvate or [1-14C] -lactate to chlorhexidine was observed. The formation of CHDI-B by the incorporation of lactate was considered to occur after the latter's oxidation to pyruvate. The antibacterial activities of CHDI-B and other related compounds decreased to 1/5 - 1/10 that of chlorhexidine. It was thought that the modification of chlorhexidine is one of the resistant mechanisms of A-3.
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© The Society for Antibacterial and Antifungal Agents, Japan
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