抄録
A bis-quaternary ammonium compound (bis-QAC), N, N'-hexamethylenebis (4-carbamoyl-1-decylpyridinium bromide) (D-38), which has 6 carbon atoms in the connecting methylene chain and 10 carbon atoms in the N-alkyl chain, was synthesized and characterized. D-38 exhibited a wide-ranging and effective antimicrobial action against both bacteria and fungi, compared with those of typical bactericides, such as benzyldodecyldimethylammonium chloride (BAC) and cetylpyridinium chloride (CPC), or popularly-used fungicides, such as 2-(4-thiazolyl) benzimidazole (TBZ) and 1, 2-benzisothiazol-3-one (BIT). D-38 showed a high bactericidal activity in the ranges of pH 5 to 8.5, and 10 to 40°C, in contrast to mono-QAC, N-dodecylpyridinium iodide (P-12), and the activity of D-38 was little influenced by pH and temperature. Furthermore, urethane sheets containing D-38 were prepared for practical use, and the antibacterial and antifungal efficiency was evaluated. Tests on the antibacterial efficiency of the D-38 sheets were carried out against two strains of bacteria (Staphylococcus aureus IFO 12732, Escherichia coli IFO 3972) according to the film covering method. Additionally, tests on the fungus resistance of the sample were performed by using the mixed spore suspension (Aspergillus niger IFO 6341, Penicillium citrinum IFO 6352, Rhizopus oryzae IFO 31005, Cladosporium cladosporioides IFO 6348, Chaetomium globosum IFO 6347). The growth of both bacteria and fungi was inhibited on sheets containing D-38.
