Bio-antimutagenic and Microbicidal Activities of 1-(2-Oxocyclopentyliden)-3-Oxadecane and the Derivatives against Mutagenic Escherichia coli WP2 B/r trp

抄録

Since 1-(2-oxocyclopentyliden)-2-alkanols (1) showed enhanced bio-antimutagenic activity against UV-induced mutagenic Escherichia coli WP2 B/r trp, 1-(2-oxocyclopentyliden)-3-oxaand 3-thiaalkanes (4 and 7) and 10-(2-oxocyclopentyliden)-8-oxadecanol (5) were synthesized, and their bio-antimutagenic and bactericidalactivity were measured. 10-(2-Oxocyclopentyliden)-8-oxadecanol (5) showed weakactivity (AD₅₀, 95.5 μg/ml), while 1-(2-oxocyclopentyliden)-3-oxanonane (4a) and 1-(2-oxocyclopentylidene)-3-thianonane (7) showed bactericidal activity (ID₅₀, 7.5 and 11.0 μg/ml, respectively).