The Journal of Biochemistry
Online ISSN : 1756-2651
Print ISSN : 0021-924X
Protozyme: Emerging Evidence in Nature
Yasuhiro AnrakuRyogo Hirata
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1994 年 115 巻 2 号 p. 175-178

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The VMA1 locus in Saccharomyces cerevisiae contains a nested genetic element, the VDE gene, and expresses two functional proteins. A single VMA1 translational product seems to catalyze a self protein splicing in which an internal domain is excised out to produce a site-specific DNA endonuclease and the N-and C-domains are ligated by a transpeptidation reaction to yield a catalytic subunit of the vacuolar ATPase. Accumulating evidence in the past few years suggests that the VMA1 locus encodes a protozyme (for protos en zym_??_) which has dual roles in life as a protean catalyst for self protein splicing and for self gene homing. Four protozymes that share a common mechanism in protein splicing have been found in four organisms covering three maior nhvlogenic trees.
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© The Japanese Biochemical Society
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