抄録
1. When glucosamine ehlorhydrate was transferred to a rabbit per os in dosis of 2gm. per kgm body weight, it is scarcely detected in blood. In urine it appears ad maximum between the 5th and the 7th hour after ingestion. The renal threshold of this compound is very low.
At the fifth hour, it is piled up the most in the mucosa of small intestine and next to it in liver, kidney, and the mucosa of stomach. The amount in pancreas was almost negligible.
The capacity of the body to tolerate it is less than 2gm. for kgm body weight.
2. When ingested subcutaneously, it appeared quickly in urine and the content of blood was highest at between the second and the third hour. At the third hour, the distribution of the substance among tissues was in the following order, decreasing from left to right.
Liver, kidney, stomach mucosa.
Besides these organs, the mucous membrane of the small intestine, pancreas and lung were found to have caught it distinctly.
Sincere thanks are due to Professor K. Kodama for criticisms and advice; to Dr. M. Mita, Professor of Pediatry, for encouragement; and to Assistant Professor H. Masamune for kind direction throughout this investigation.
