ON BLOOD ACETALDEHYDE

I. Experimental studies on blood acetaldehyde. II. Clinical investigations on blood acetaldehyde

抄録

The experimental and clinical results on blood acetaldehyde can be summarised as follows:
1. After giving glucose, both blood acetaldehyde and blood sugar gradually increase and the former reaches its maximal value after two or three hours. We can see almost the same results after the giving of fructose.
2. Upon providing glucose to dogs nourished with a proteinfat diet, under a fasting condition or poisoned with carbon tetrachloride, the dietary hyperglycemia appeared stronger than in cases of mixed diet. The maximal increase value of blood acetaldehyde was just the opposite, being smaller than in cases of mixed diet.
3. When fructose was given to dogs fed on a protein-fat diet, in a fasting condition or poisoned with carbon tetrachloride, the disturbances of the fructose metabolism were noticeable, and the maximal increase value of the blood acetaldehyde in each case is smaller than in that of a mixed diet.
4. When fructose was given to dogs in normal condition or under experimental disturbances of sugar metabolism, the maximal increase value of blood acetaldehyde was larger than that after the giving of glucose.
5. The maximal increase value of the blood acetaldehyde increases after insulin injection and decreases when adrenalin is injected.
6. The maximal increase value of blood acetaldehyde of patients with diabetes mellitus was in all cases smaller than that of healthy persons. Moreover, the higher the hyperglycemia of the patients was, the smaller were the maximal increase values.
7. Among patients with Basedow's disease, pulmonary tuberculosis and diseases of the liver and the gall-bladder system, those who had disturbances of the sugar metabolism showed a smaller maximal increase value of blood acetaldehyde than that of normal persons.
8. In my experimental as well as clinical investigations, the maximal increase value of blood acetaldehyde of individuals having disturbances of the sugar metabolism was smaller than that of normal cases, That is, when disturbances of the sugar metabolism are seen, a hindrance of the oxydation of sugar also exists.
In closing I wish to express my heartiest thanks to my esteemed director, Prof. Dr. Kageura for his kind efforts in directing this research. I wish also to express my deepest gratitude to assistant Prof. Dr. Hara for his kind assistance.