ACTION OF ALLOXAN ON ADRENALECTOMIZED RABBITS
1951 年 38 巻 1 号 p. 37-43
詳細
1951 年 38 巻 1 号 p. 37-43
1. The alloxan-treatment of adrenalectomized rabbits caused almost no elevation of blood sugar.
2. When alloxan-treated adrenalectomized rabbits were injected with glucose, the recovery of blood sugar level was somewhat retarded, and the elevation of blood pyruvate or lactate during the hyperglycemic phase, which was observed on the rabbits not treated with alloxan, was not observed.
3. As the previous communication (1) indicates, when normal rabbits were treated with alloxan, the initial hyperglycemia took place and no decrease of blood pyruvate and lactate was observed during the following hypoglycemic phase. Now, when adrenalectomized rab-bits were treated with alloxan, this initial hyperglycemia was not distinctly observed, and the blood pyruvate and lactate decreased during the following hypoglycemic phase.
This work was supported by a grant from the Department of Educa-tion for Scientific Research. The author gratefully acknowledges the guidance and helpful advice of Prof. N. Shimazono.
