ON THE INFLUENCE OF THE ADMINISTRATION OF AMINO ACIDS UPON THE DISTRIBUTION OF PORPHY-RIN BODIES IN TISSUES

I. THE INFLUENCE OF THE ADMINISTRATION OF SULPHUR CON-TAINING AMINO ACIDS

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1. Sulphur containing amino acids in general increase the metal-loporphyrin of tissues markedly, there being no decrease in the porphyrin of tissues.
2. The increase of tissue metalloporphyrin becomes most marked at the end of a certain time after the administration and then it gradually decreases.
3. The change in tissue metalloporphyrin takes place most marked-ly and rapidly with cysteine and least markedly and slowly with methio-nine.
4. With cysteine the increase in tissue metalloporphyrin is most marked when given in such doses as 0.05mg./100 g. and with cystine and methionine 0.1mg/ 100 g. and the change is less marked when they are given in larger doses.
5. At the end of 24 hours after the administration of cystine or cysteine in such a dose as 5 mg./100 g. liver metalloporphyrin decreases beyond the normal value and the decrease is more marked with cysteine.
6. Repeated administration of cystine in dose of 0.5 mg./100 g, causes often the decrease of liver metalloporphyrin.
7. The repeated administration of methionine even in such a large dose as 6mg./100 g. causes no decrease of liver metalloporphyrin.
8. The above results indicate that the physiological action of sulphur containing amino acids manifests itself through the change in the metalloporphyrin of tissues.