“ALLITHIAMINE” A NEWLY FOUND DERIVATIVE OF VITAMIN B₁

II. THE EFFECT OF ALLITHIAMINE ON LIVING ORGANISM

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The results of our study on the effect of allithiamine and its homologue on experimental animals and human subjects may be summarized as follows:
1. Allithiamine and its homologue are less toxic than thiamine.
2. Allithiamine and its homologue are more active on growth of rats than thiamine.
3. Allithiamine and its homologue are of curative effect on thiamine deficiency in experimental animals.
4. Allithiamine and its homologue are absorbed from intestine far more easily than thiamine. Intestinal uptake increases proportionately to the amount of oral intake.
5. Allithiamine and its homologue cause a marked elevation in blood level of thiamine in animals and human subjects.
6. Phosphorylation takes place on allithiamine more easily than thiamine.
The authors wish to thank Dr. U. Miura, Kyoto University, for encouragement during the course of this investigation. The experiments were aided by a grant from the Ministry of Education.