STUDIES ON THE TRICARBOXYLIC ACID CYCLE IN TUBERCLE BACILlUS

I. SOME PROPERTIES OF THE ENZYME SYSTEMS

抄録

We have separated from Mycobacterium avium the enzymes involved in the TCA cycle, namely aconitase, citric (probably isocitric), a-ketoglutaric, and succinic oxidases, fumarase, L-malic oxidase, oxalacetic decarboxylase and citrate synthesis enzymes in cell-free state, and the extraction procedures and some properties of these enzymes were described here.
It is concluded that the TCA cycle operates actively in the terminal respiration of Mycobacterium avium.
The authors wish to express their gratitude to Professor Saburo Watanabe, the chief of the Toneyama Institute for Tuberculosis, and Professor Shiro Arabori of the Department of Chemistry, Faculty of Science, Osaka University not only for their criticism, but also for their interest and encouragement during this investigation.