STUDIES ON XANTHURENIC ACID
XIII. EFFECT OF 5-HYDROXYANTHRANILIC ACID ON THE FORMATION AND ON ITS CONJUGATING REACTION OF XANTHURENIC ACID IN ALBINO RAT
1956 年 43 巻 4 号 p. 437-443
詳細
1956 年 43 巻 4 号 p. 437-443
From the experiments stated above, it is now clear that 5-hydroxy-anthranolic acid, a tryptophan metabolite postulated by Y. Kotake as one of biocatalysors, acts inhibitory to the output of xanthurenic acid. Both methionine and 5-hydroxyanthranilic acid are capable of restoring the conjugating reaction of xanthurenic acid weakened by administration of sodium butyrate in the body.
From these findings, it is possible to conclude that 5-hydroxy-anthranilic acid inhibits the formation of xanthurenic acid and ac-celerates its conjugating reaction and as the results the accumulation of xanthurenic acid in the body and the appearance of diabetic symptoms are prevented.
We wish to thank heartily to Prof. Yashiro Kotake, for his advice and revision and also heartily thank to Prof. K. Kodama, for his revision.
