抄録
1. Using the in vitro method and S35 DL-methionine, we tested the rate of amino acid transfer from the mucosa to the serosa of rat intestine and vice versa. The transfer rate of the L-isomer from mucosa to serosa was shown to be much faster than that of the D-isomer. However, when the same experiments were carried out from serosa to mucosa, there was no difference between the L- and D-isomer. In this case, the rate of transfer was reduced to that of free diffusion.
2. In B6 deficiency induced by L-penicillamine in vivo, the rate of absorption of the L-isomer is decreased and restored by B6 to the normal rate. No acceleration of the rate of absorption was observable with the D-isomer. The effect of B6 was not duplicated by other vitamins such as B1 or B2. The absorption of glucose under the same experimental conditions was not influenced by B6. Furthermore, the rate of L-methionine absorption was not affected in B1 deficiency.
3. Evidence is given that the animals after injection of L-penicillamine were in B6 deficiency.
