INTESTINAL ABSORPTION OF AMINO ACIDS

II. ISOTOPIC STUDIES ON THE AMINO ACIDS ABSORPTION FROM THE INTESTINE USING S³⁵ DL-METHIONINE AND C¹⁴ DL-VALINE

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1. Observation was made on the metabolic pattern of amino acids in the intestinal wall and portal blood after absorption of S³⁵ DL-methionine and C¹⁴ DL-valine.
2. Amino acids after entering the intestinal tissues seem to be independent of the pool of amino acids in the tissues.
3. About half the methionine observed was oxidized to methionine-sulfoxide in the intestine, and was again reduced in the portal circulation.
4. The above oxidoreduction of methionine appears to be coupled with its mechanism of absorption.
5. C¹⁴ DL-valine enters the portal blood without any modification.