Studies on the Toxic Substances Isolated from Mycobacteria
I. Toxic Glycolipids of Mycobacterium fortuitum and Atypical Mycobacteria Strain P16
1962 年 52 巻 2 号 p. 82-91
詳細
1962 年 52 巻 2 号 p. 82-91
Purified wax was extracted from Mycobacterium fortuitum and atypical mycobacteria strain P16. Highly purified toxic glycolipid was obtained from purified wax by the repeated column chromatographies on sillica gel, silicic acid and magnesium silicate. By means of chemical analysis and toxicity test, it was shown that toxic glycolipids were identical with cord factor of tubercle bacilli. The toxic lipid contents of Mycobacterium fortuitum and atypical mycobacteria strain P16 were lower than those of various tubercle bacilli strains. Acid component obtained from toxic glycolipid of atypical mycobacteria strain P16 was assumed to have the formula C68H136O4.
The authors express their deep gratitude to Dr. H. Oura, School of Pharmacy, Toyama University, for his helpful criticism and Dr. A. Yasuda and Dr. Y. Fujiwara for cultivation of bacilli. The authors indebted to Mrs. S. Matsuba for elementary analysis, and to Mr. K. Hikita for spectral measurment. A part of this work was supported by a Grant-in-Aid for Scientific Reserch from the Ministry of Education, to which the authors' thanks are due.
