Abstract
Escherichia coli and a variety of other microorganisms can reduce phenazine 5, 10-di-N-oxide to phenazine. This reduction proceeds more rapidly under anaerobic conditions and the aerobic reaction can be stimulated by various hydrogen donors. 2-Hydroxy- and 2-methoxyphenazine di-N-oxides and phenazine 5-N-oxide are also reducible by E. coli cells. The effects of pH and several inhibitors of this reduction were studied.
The authors wish to express their thanks to Dr. R. Sato of the Institute for Protein Research, University of Osaka, for his guidance and encouragements during the course of this investigation.
