Fatty Liver Induced by 2-Ethylthioisonicotinamide (Ethionamide)

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Liver lipid content of rats fed a 0.3% 2-ethylthioisonicotinamide diet for one week in-creased to about twice that of rats on a control diet. Accumulated lipids were chiefly triglycerides.
Intraperitoneal injection of phosphoryl-choline, cytidine and 5-aminoimidazole-4-car-boxamide showed complete inhibition of 2-ethylthioisonicotinamide fatty liver, while cytidine diphosphate choline, aspartylcholine and uridine also showed the considerable inhibition but not to the level of lipid content in the control group. The preventive effect to the 2-ethylthioisonicotinamide fatty liver of choline chloride, methylglycine, earni-thine, ethanolamine and orotic acid was not observed.
The mechanism of induction of 2-ethyl-thioisonicotinamide fatty liver was discussed.