Studies on Mercapturic Acids
Effect of Some Aromatic Compounds on the Level of Glutathione and the Activity of Glutathionase in the Rat
1966 年 59 巻 3 号 p. 209-215
詳細
1966 年 59 巻 3 号 p. 209-215
1. Six hours after the administration to the rat of several compounds known to be excreted as mercapturic acids, glutathione level in the liver fell markedly but that in the blood was not significantly affected.
2. No significant change in glutathionase activity was observed in the kidney of rats dosed with aromatic compounds.
3. On repeated administration of bromo-benzene to the rat, glutathione levels in the liver and blood were found to increase. On the other hand, glutathionase activity in the kidney and excretion of mercapturic acid were found to decrease.
