Department of Tissue Physiology, Medical Research Institute, Tokyo Medical and Dental University Department of Dermatology, Osaka University School of Medicine
Tomoyuki KAWAMOTO
Department of Tissue Physiology, Medical Research Institute, Tokyo Medical and Dental University
Hisae HORI
Department of Tissue Physiology, Medical Research Institute, Tokyo Medical and Dental University
Yutaka NAGAI
Department of Tissue Physiology, Medical Research Institute, Tokyo Medical and Dental University
Collagenase inhibitors with molecular weights of about 6, 000 and 12, 000 were isolated from latent chick skin collagenase treated with 3M NaI and from the culture medium of embryonic skin explants. It is suggested that these inhibitors, which are possibly derived from connective tissue macromolecule metabolites, are candidates for regulating factors of collagenase activity in vivo.
