2018 Volume 8 Issue 1 Pages 115-121
Purpose: Periodontal disease is a chronic inflammatory disease that affects the periodontal supporting tissues of teeth. The aim of this study is development of a new local drug delivery system (LDDS) containing salicylic acid (SA) or metronidazole (MTZ) to apply in a dental intra- pocket for periodontitis treatment. The new dental pocket drug delivery system (DPDDS) can be easily administrated by the periodontitis patient, the oral tissues can be return and maintained to a healthy state, so it is useful as a non-surgical local therapy. Methods: The filaments were prepared by physical mixing of 10 wt% of hydrophilic drug (SA) or hydrophobic drug (MTZ) with different kinds of polymers including Soluplus® (SP), and Hydroxypropyl cellulose (HPC). Then the filaments were fabricated by the hot melt extrusion (HME) method. We obtained a filament with two kinds of shapes in the same weight which are 10 mm length/500 μm diameter and 1.5 mm length/1500 μm diameter. Both SA and MTZ were release from filament in simulated saliva was determined by UV-spectrometer. The scanning electron microscope (SEM) was used for observed the shape and determined the distribution of the drugs on the surface of the filaments. Results: According to in vitro study, the mechanism of drug release which followed Korsmeyer-Peppas kinetics model mostly indicated anomalous (non-Fickian) diffusion. While release kinetic profile which explained the drug release rate was followed Higuchi’s kinetics model. The results shown SP made drugs release faster than HPC. Comparison between short/thick and long/thin filaments containing MTZ showed the short/thick had slower MTZ release than long/thin filament. The SEM images shown some particles of drug distributed thoroughly filament which confirmed a solid dispersion dosage form. Conclusion: These results suggested that filaments of SA and MTZ could be applied for periodontitis treatment using this DPDDS.
