Biomedical Research
Online ISSN : 1880-313X
Print ISSN : 0388-6107
Communication
Effect of laughter on salivary endocrinological stress marker chromogranin A
Masahiro TODAShinsuke KUSAKABEShingo NAGASAWAKazuyuki KITAMURAKanehisa MORIMOTO
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JOURNALS FREE ACCESS

2007 Volume 28 Issue 2 Pages 115-118

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Abstract

We investigated the effect of laughter on salivary endocrinological stress marker chromogranin A (CgA). In saliva samples collected from 11 healthy males before and after watching a comic film or a non-humorous control film, salivary CgA levels were determined by enzyme-linked immunosorbent assay (ELISA). Samples taken after watching the comic film showed increased levels of CgA. This tendency was more pronounced in individuals with lower initial levels of stress. The control samples showed no significant change in CgA levels. Stress score, subjectively evaluated using a visual analog scale, decreased significantly after watching the comic film. These findings suggest that, in addition to a stress relief effect, laughter can bring about feeling uplifted or fulfilled.

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© 2007 Biomedical Research Press
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