IMMUNOHISTOCHEMICAL DEMONSTRATION OF A CEREBELLAR PROTEIN (SPOT 35 PROTEIN) IN SOME SENSORY　CELLS OF GUINEA PIGS

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Spot 35 protein (S 35) is a soluble protein which has been shown to occur specifically in Purkinje cells. The present study deals with immunohistochemical demonstration of S 35 in the sensory organs of guinea pigs. The S 35-like immunoreactivity was recognized in gustatory cells, hair cells in the organ of Corti and olfactory receptor cells. In the retina, horizontal neurons stained positively, but rods and cones were negative in reaction. Since we have demonstrated an extensive distribution of S 35 in peptidic endocrine cells, it is suggested that many, if not all, paraneurons of both endocrine and sensory nature share this protein with cerebellar Purkinje cells.