2005 年 45 巻 6 号 p. 308-313
The sensor of blue-light using FAD (BLUF), a novel blue-light photoreceptor that uses flavin as a chromophore, has been found to control wide variety of light-dependent physiological responses in several microorganisms. The photocycle reaction of BLUF proteins is unique, which is characterized by a 10 nm red shift of the absorption of bound flavin in the visible region spectrum. In this review, physiological functions of several BLUF proteins are summarized. Molecular mechanisms of photocycle reaction of BLUF proteins are also discussed based on the recent advances in their spectroscopic and structural analyses.