Abstract
Homologous recombination promotes faithful segregation of homologous chromosomes during meiosis. Two RecA homologues, Rad51 and Dmc1, work together to catalyze homology search and strand exchange process in the recombination. We recently identified a protein complex containing two meiosis-specific proteins, Mei5 and Sae3, which promotes the assembly of Dmc1 on the Rad51 ensembles. In this review, I will discuss the function of Dmc1-containing protein machinery in meiotic-recombination and possible asymmetric distribution of the two RecA homologues on chromosomes.
