2007 年 47 巻 3 号 p. 160-166
Transcription factors play essential roles in the gene regulation. Structural data on protein-DNA complexes provide clues for understanding the mechanism of protein-DNA recognition. Analysis of these structures has shown that there is no simple one-to-one correspondence between bases and amino acids within protein-DNA complexes, and that the recognition is rather redundant and flexible. We explain the mechanism of such redundant and flexible recognition of DNA sequences by proteins, and describe the methods to predict target DNA sequences in the genome.