生物物理
Online ISSN : 1347-4219
Print ISSN : 0582-4052
ISSN-L : 0582-4052
解説
タンパク質のDNA認識メカニズムと予測
皿井 明倫河野 秀俊
著者情報
ジャーナル フリー

2007 年 47 巻 3 号 p. 160-166

詳細
抄録

Transcription factors play essential roles in the gene regulation. Structural data on protein-DNA complexes provide clues for understanding the mechanism of protein-DNA recognition. Analysis of these structures has shown that there is no simple one-to-one correspondence between bases and amino acids within protein-DNA complexes, and that the recognition is rather redundant and flexible. We explain the mechanism of such redundant and flexible recognition of DNA sequences by proteins, and describe the methods to predict target DNA sequences in the genome.

著者関連情報
© 2007 by THE BIOPHYSICAL SOCIETY OF JAPAN
前の記事 次の記事
feedback
Top