MFS輸送体の構造とその輸送機構

抄録

Major facilitator superfamily (MFS) is the largest family of secondary transporters. MFS includes uniporter, antiporter and symporter. The structure of oxalate transporter reported by electron crystallography showed a “closed” conformation and it revealed remarkably symmetric architecture with twelve helices surrounding a central cavity. Some of the structures reported by X-ray crystallography showed “open” conformation. Comparing these structures, a transport mechanism based on the simple domain movement has been proposed.