抄録
Cell-modeling research has been attracting increasing interests, as a potential methodology to understand the structure and function of living cells. We describe the recent development on the studies toward the construction of an artificial-cell-model. It is shown that protein synthesis of gene transcription/translation reaction proceeds within lipidic artificial-cell-models (in lipo), cell-sized liposomes, and water-in-oil droplets. As an experimental example, we describe the in lipo synthesis of functional membrane proteins. We also present the effects of confinement on the structural transition of actin filaments inside cell-sized compartments. We propose a theoretical model on the epigenetic control of the On/Off switching of genetic activity.
