2011 年 51 巻 3 号 p. 124-127
DNA methylation is a heritable epigenetic mark that enables the tissue-specific gene expression accompanied by modulation of chromatin structure. Interpretation and maintenance of DNA methylation pattern on genome are crucial for a wide range of biological processes such as genomic imprinting, embryogenesis and carcinogenesis. Recent crystallographic studies of methylated DNA binding proteins have provided a new insight into the molecular mechanisms underlying epigenetic regulation. This review focuses on a structure basis for strict recognition of the methylation status of the CpG site by DNA binding domains in MBD family proteins and UHRF1.