生物物理
Online ISSN : 1347-4219
Print ISSN : 0582-4052
ISSN-L : 0582-4052
総説
エピジェネティクス制御におけるメチル化DNAの認識
有吉 眞理子白川 昌宏
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ジャーナル フリー

2011 年 51 巻 3 号 p. 124-127

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DNA methylation is a heritable epigenetic mark that enables the tissue-specific gene expression accompanied by modulation of chromatin structure. Interpretation and maintenance of DNA methylation pattern on genome are crucial for a wide range of biological processes such as genomic imprinting, embryogenesis and carcinogenesis. Recent crystallographic studies of methylated DNA binding proteins have provided a new insight into the molecular mechanisms underlying epigenetic regulation. This review focuses on a structure basis for strict recognition of the methylation status of the CpG site by DNA binding domains in MBD family proteins and UHRF1.

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© 2011 by THE BIOPHYSICAL SOCIETY OF JAPAN
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