抄録
Centrioles are cell organelles consisting of nine triplet microtubules arranged in rotational symmetry. This structure is highly conserved among various eukaryotic organisms and serves as the template for the “9 + 2” or “9 + 0” structures of ciliary axonemes. How this nine-fold symmetrical structure forms is a long-standing question. Recently, genetic approaches using Chlamydomonas revealed that the cartwheel, a sub-centriolar structure with a hub and nine spokes, plays a pivotal role in the establishment of nine-fold symmetry, and that a protein called SAS-6 is a key component of the cartwheel assembly. This review summarizes the Chlamydomonas studies and recent advances in the understanding the SAS-6 function.
