生物物理
Online ISSN : 1347-4219
Print ISSN : 0582-4052
ISSN-L : 0582-4052
解説
シグナル伝達機構による時間情報コード
久保田 浩行黒田 真也
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2013 年 53 巻 4 号 p. 184-189

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Cellular responses, such as cell fate decision and hormonal regulations, can be regulated by distinct temporal patterns of signaling molecules. However, how temporal patterns of signaling molecules determine the cellular responses remains largely unknown. Recently, we have proposed the concept of “temporal coding”, by which a single molecular species can encode multiple information through its temporal patterns. We found that signaling pathways can process information of stimulation patterns depending on their network motif and kinetics, and cells can regulate downstream molecules depending on stimulation pattern. Thus, “temporal coding” appears to serve as an information-embedding strategy to elicit specific cellular responses.

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© 2013 by THE BIOPHYSICAL SOCIETY OF JAPAN
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