ハイブリッドリポソームによるがん治療と分子メカニズム

抄録

We have produced hybrid liposomes (HL) which can be prepared by sonication of a mixture of vesicular and micellar molecules in a buffer solution. Some interesting results are as follows; HL remarkably inhibited the growth of cancer cells along with apoptosis in vitro and in vivo. Anticancer effects increased with a growth in membrane fluidity of HL and fluidity of plasma membranes of cancer cells. In clinical applications, prolonged survival and remarkable reduction of neoplasm were attained in patients with lymphoma after the treatment with HL without any side effects after the approval of the bioethics committee.