解説
キネシン型分子モーターの構造変化と動作機構
2014 年 54 巻 3 号 p. 133-139
詳細
2014 年 54 巻 3 号 p. 133-139
Molecular motor kinesins move processively along microtubules by using energy derived from ATP hydrolysis. Almost all of the intermediate structures of this ATPase reaction cycle have been solved for the monomeric kinesin KIF1A. Based on this structural information, we present here the common atomic mechanisms of kinesin motility, which can be applied not only to the monomeric kinesins but also to the dimeric kinesins. Structural studies have suggested that kinesins accomplish their mission by utilizing the evolutionary conserved strategy among the various ATPases/GTPases/kinases in which they use the energy from the ATP/GTP hydrolysis to attach/detach to/from their effectors.
