生物物理
Online ISSN : 1347-4219
Print ISSN : 0582-4052
ISSN-L : 0582-4052
総説
天然変性,ハブ性,細胞内局在を整理する
太田 元規福地 佐斗志小池 亮太郎
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2017 年 57 巻 2 号 p. 085-089

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Protein-protein interactions are fundamental for all biological phenomena. The hub proteins interacting with a number of partner proteins play the vital role in the protein-protein interaction network. We investigated the subcellular localization of proteins in the network, and found that the proteins localized in the multiple subcellular compartments, especially the nucleus and cytoplasm, tend to be hub proteins. Examination on keywords associated with the proteins suggested that those related to post-translational modifications (PTMs) and transcriptions contributed to numerous interactions. Triggered by PTMs in the intrinsically disordered regions, they change interaction partners in the protein complex, and are translocated from cytoplasm to nucleus.

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© 2017 by THE BIOPHYSICAL SOCIETY OF JAPAN
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