総説
骨はどのようにして維持されるのか：相反する機能を持つ細胞による動的な制御機構
キーワード:
intravital imaging,
two-photon excitation microscopy,
bone remodeling,
osteoclast,
osteoblast
2020 年 60 巻 4 号 p. 227-230
詳細
2020 年 60 巻 4 号 p. 227-230
We recently established the intravital imaging system for visualizing the bone tissues in living mice using two-photon excitation microscopy. By means of this system, we succeeded in visualization of direct cell-cell contact between osteoclasts and osteoblasts. In addition, we revealed that this intercellular interaction could regulate the bone remodeling. Our intravital bone imaging system would be useful for the analysis of pathology of various bone diseases and the evaluation of the effect of new drug.
