特集：ウイルス感染症に取り組む生物物理学 総説
SARS-CoV-2タンパク質構造モデルによる薬剤候補予測
2021 年 61 巻 2 号 p. 102-106
詳細
2021 年 61 巻 2 号 p. 102-106
The novel coronavirus disease (COVID-19) pandemic has emerged in late 2019 and rapidly spread all over the world. In order to assist structure-based discovery efforts for repurposing drugs against the infectious disease, we constructed homology models of SARS-CoV-2 proteins. We identified several potential drugs by comparing the ligand molecules in the template structures with approved or experimental drugs and compounds of natural drugs, including carfilzomib, sinefungin, tecadenoson, and trabodenoson, that would be further investigated for their potential for treating COVID-19.
