総説
細胞スケール不均一弾性場における細胞形状と運動のダイナミクス
2021 年 61 巻 3 号 p. 152-156
詳細
2021 年 61 巻 3 号 p. 152-156
Microscopic heterogeneity of the extracellular mechanical environment is an essential factor in controlling cell migration such as in morphogenesis, wound healing, and cancer metastasis. For example, a monotonic, microscopic stiffness gradient can induce directional cell migration, so-called durotaxis. However, it has been unclear how cell migration is modulated under a cell-scale heterogeneity of matrix-elasticity. Here, to understand the cell migration on a matrix with heterogeneous elasticity distribution, we review experiments about the dynamics of cell shape and motion on hydrogels with various elasticity distributions, and theoretical works for the cell migration based on a model of cell-shaping dynamics.
