Seibutsu Butsuri
Online ISSN : 1347-4219
Print ISSN : 0582-4052
ISSN-L : 0582-4052
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The Rheology of the Dynamic 3D Genome Organization
Soya SHINKAI
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2021 Volume 61 Issue 5 Pages 293-297

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Abstract

Chromatin fibers, as the substance of the genome, are biopolymers packed inside the cell nucleus. High-throughput chromosome conformation capture (Hi-C) techniques have revealed the 3D genome organization for over a decade. Meanwhile, live-cell imaging experiments have shown the dynamic nature of chromatin. To bridge the gap between genome 3D structure and dynamics, we have developed a computational method for deciphering Hi-C data by polymer modeling. Here we provide a way to uncover the rheological properties of the dynamic 3D genome organization.

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© 2021 by THE BIOPHYSICAL SOCIETY OF JAPAN
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