The Rheology of the Dynamic 3D Genome Organization

Abstract

Chromatin fibers, as the substance of the genome, are biopolymers packed inside the cell nucleus. High-throughput chromosome conformation capture (Hi-C) techniques have revealed the 3D genome organization for over a decade. Meanwhile, live-cell imaging experiments have shown the dynamic nature of chromatin. To bridge the gap between genome 3D structure and dynamics, we have developed a computational method for deciphering Hi-C data by polymer modeling. Here we provide a way to uncover the rheological properties of the dynamic 3D genome organization.