Seibutsu Butsuri
Online ISSN : 1347-4219
Print ISSN : 0582-4052
ISSN-L : 0582-4052
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Volume 63, Issue 1
Issue 365
Displaying 1-16 of 16 articles from this issue
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  • Enzymes and Liquid-Liquid Phase Separation: A New Era for the Regulation of Enzymatic Activity
    Mirco DINDO, Alessandro BEVILACQUA, Paola LAURINO
    2023 Volume 63 Issue 1 Pages 12-15
    Published: 2023
    Released on J-STAGE: March 25, 2023
    DOIhttps://doi.org/10.2142/biophys.63.12
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    Liquid-liquid phase separation (LLPS) is recognized as a mechanism for regulation of enzymatic activity. Biochemical mechanisms include concentrating reactants to enhance reaction rates or sequester enzymes and reactants from each other to reduce the reaction rate. On the other hand, LLPS might also regulate the diffusion of small molecules or important parameters for enzymatic activity (such as modulators, macromolecular crowding and changing the media physicochemical features) increasing or decreasing the reaction rate of the enzymes. Furthermore, the co-compartmentalization of specific enzymes can favour or speed up specific metabolic fluxes. Here, we discuss how LLPS contributed to generate a new era for enzyme regulation and the new possible subtle regulation mechanisms still unexplored.

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  • Structural Biology of Prostaglandin Receptors
    Ryoji SUNO, Takuya KOBAYASHI
    2023 Volume 63 Issue 1 Pages 16-20
    Published: 2023
    Released on J-STAGE: March 25, 2023
    DOIhttps://doi.org/10.2142/biophys.63.16
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    Prostaglandins (PGs), lipid mediators, exert various effects in vivo through receptor-mediated signal transduction, and the elucidation of the molecular mechanisms of signal transduction by structural biology of PG receptors is expected to contribute to drug discovery. We have elucidated the molecular mechanisms of ligand binding mode, signal transduction mechanism, and G protein selectivity through structural analysis of PG receptors. In this paper, we would like to introduce the structure and function of GPCRs revealed through structural biology of PG receptors.

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