In the last decade, SQUID "Superconducting Quantum Interference Device" has been developed in low temperature physics area. The SQUID is a device to which quantum effect in superconductivity is applied, and is used as a high sensitive magnetometer, low level current detector etc.. In this report, basic concepts and applications of this device are reviewed, and then our development on this device for biological measurements is presented. Possibilities of kinetic measurements of some reaction systems are also discussed.