細胞内脂質輸送と膜融合
蛍光脂質を用いた細胞内脂質のダイナミックスの解析
1990 年 30 巻 3 号 p. 133-140
詳細
1990 年 30 巻 3 号 p. 133-140
Intracellular lipid traffic was studied using fluorescent lipid analogs. 1) Fluorescent ceramide analog was metabolized in the Golgi apparatus and transported to the plasma membrane most likely via vesicular traffic. 2) Phosphatidylcholine liposomes were shown to fuse with the Golgi apparatus in an ATP-dependent manner. 3) Exogenous fluorescent phosphatidylserine analog was transported to mitochondria through the Golgi apparatus. Involvement of plasma membrane "flippase" in the uptake of exogenous phosphatidylserine was suggested.
