抄録
Soluble proteins consist of one to several globular functional domains. A globular domain is decomposed into several modules. Module is a sub-structure within a globular domain and it has a compact conformation consisting of a contiguous sequence of 10 to 40 amino acid residues. Close correlation of module boundaries with intron positions implies that a gene encoding a globular functional domain was created by joining exons in early evolution. Some introns seem to be deleted on different lineages in evolutionary time scale.
