膜タンパク質を見て,引っ張る
膜骨格による動的な制御機構を探る
1997 年 37 巻 6 号 p. 244-248
詳細
1997 年 37 巻 6 号 p. 244-248
Interaction between erythrocyte band 3 and the membrane skeleton was analyzed at a level of individual molecules. By observing the movement of band 3 molecules and by dragging the membrane skeleton using optical tweezers, it was found that the cytoplasmic portion of band 3 collides with the membrane skeleton, which causes temporal confinement of band 3 within a mesh of spectrin network of-100nm ∅. Band 3 hops to an adjacent mesh at an average of once every 350 ms. These results demonstrate that single molecule observation/manipulation techniques provide unique and valuable tools for the study of living cells.
