Biophysics and Physicobiology
Online ISSN : 2189-4779
Review Article
Crystallographic analysis of the overlapping dinucleosome as a novel chromatin unit
Masahiro NishimuraKayo NozawaHitoshi Kurumizaka
Author information
JOURNALS FREE ACCESS

2018 Volume 15 Pages 251-254

Details
Abstract

Recent evidence has suggested that chromatin is not simply repeats of the canonical nucleosome, called the “octasome”, but may include diverse repertoires of basic structural units. During the transcription process, a nucleosome is repositioned by a chromatin remodeler and collides with a neighboring nucleosome, thus creating an unusual nucleosome substructure termed the “overlapping dinucleosome”. We previously developed a method for the large-scale preparation of the overlapping dinucleosome. This method enabled us to solve the crystal structure of the overlapping dinucleosome, which revealed an unexpected structure composed of an octameric histone core associated with a hexameric histone core lacking one H2A-H2B dimer.

Information related to the author
© 2018 THE BIOPHYSICAL SOCIETY OF JAPAN
Previous article Next article
feedback
Top