Rat Small Intestine Muscle Relaxation Alkaloids from Orixa japonica Leaves

Shinji FUNAYAMA; Rioko TANAKA; Yasuhiro KUMEKAWA; Toshiro NOSHITA; Tetsuya MORI; Tadashi KASHIWAGURA; Kiyoshi MURATA

doi:10.1248/bpb.24.100

Notes

Rat Small Intestine Muscle Relaxation Alkaloids from Orixa japonica Leaves

Shinji FUNAYAMA, Rioko TANAKA, Yasuhiro KUMEKAWA, Toshiro NOSHITA, Tetsuya MORI, Tadashi KASHIWAGURA, Kiyoshi MURATA

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Keywords: Orixa japonica, quinoline alkaloid, japonine, eduline, rat small intestine, relaxant effect

JOURNAL FREE ACCESS

2001 Volume 24 Issue 1 Pages 100-102

DOI https://doi.org/10.1248/bpb.24.100

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Abstract

Two quinoline alkaloids, japonine (1) and eduline (2) were isolated from the methanol extract of the leaves of Orixa japonica as relaxants against rat small intestine muscle. The activity of these alkaloids was comparable to that of the typical muscle relaxant papaverine (4). This is also the first report of the isolation of eduline (2) from O. japonica.

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