Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Notes
The 5-HT1A Receptor Agonist 8-Hydroxy-2-di-n-(propylamino)tetralin (8-OH-DPAT) Induces Hyperglucagonemia in Rats
Yumi SUGIMOTOIkuko KIMURAYoshiko WATANABEJun YAMADA
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2001 Volume 24 Issue 10 Pages 1191-1194

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Abstract

Effects of the 5-HT1A receptor agonist 8-hydroxy-2-di-n-(propylamino)tetralin (8-OH-DPAT) on plasma glucagon levels were investigated. 8-OH-DPAT increased plasma glucose and glucagon levels in rats. Both hyperglycemia and hyperglucagonemia elicited by 8-OH-DPAT were prevented by the 5-HT1A receptor antagonist pindolol and prior adrenodemedullation. These results suggest that increases in plasma glucagon levels induced by 8-OH-DPAT were based on the adrenaline release from the adrenal gland and its effects may contribute to its hyperglycemic effects.

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© 2001 The Pharmaceutical Society of Japan
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