Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
Notes
Anti-tumor-Promoting Activity of the Diterpene from Excoecaria agallocha. II
Takao KONOSHIMATenji KONISHIMidori TAKASAKIKiyonori YAMAZOEHarukuni TOKUDA
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Volume 24 (2001) Issue 12 Pages 1440-1442

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Abstract

Eight new diterpenoids (1—8) have been isolated from the wood of Excoecaria agallocha (Euphorbiaceae) and their inhibitory effects on the induction of Epstein-Barr virus early antigen (EBV-EA) in Raji cells were examined to search for potent anti-tumor-promoters from natural resources. Of these compounds, the secolabdane-type diterpenoid, compound 7 exhibited a remarkable inhibitory effect on EBV-EA induction, and a significant anti-tumor-promoting effect in the mouse two-stage carcinogenesis test using 7,12-dimethylbenz[a]anthracene and 12-O-tetradecanoyl-phorbol-13-acetate.

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© 2001 The Pharmaceutical Society of Japan
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