Anti-androgenic Activity of Myricae Cortex—Isolation of Active Constituents from Bark of Myrica rubra

Abstract

The aqueous ethanol extract of Myricae Cortex (bark of Myrica rubra SIEB. et ZUCC., Myricaceae) showed in vitro testosterone 5α-reductase inhibitory activity and in vivo anti-androgenic activity using growth of flank organ in castrated Syrian hamsters and/or hair regrowth after shaving in testosterone-treated C57Black/6CrSlc mice. Three constituents, myricanone, myricanol, and myricetin were identified as the main active principles.